Addendum: Wnt4 signaling prevents skeletal aging and inflammation by inhibiting nuclear factor-κB
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منابع مشابه
Wnt4 Signaling Prevents Skeletal Aging and Inflammation by Inhibiting Nuclear Factor-ÎoB
Aging-related bone loss and osteoporosis affect millions of people worldwide. Chronic inflammation associated with aging promotes bone resorption and impairs bone formation. Here we show that Wnt4 attenuates bone loss in osteoporosis and skeletal aging mouse models by inhibiting nuclear factor-κB (NF-κB) via noncanonical Wnt signaling. Transgenic mice expressing Wnt4 from osteoblasts were signi...
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ژورنال
عنوان ژورنال: Nature Medicine
سال: 2015
ISSN: 1078-8956,1546-170X
DOI: 10.1038/nm0915-1101